Palbociclib is an Orally Active CDK4 and CDK6 Inhibitor for Cancer Research
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory subunit-a cyclin. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa. What’s more, CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and...
Benufutamab (GEN1029) is a DR5-Specific Agonistic Antibody for Solid Tumor Research
Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and TNFR superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. Triggering of these receptors via TRAIL or agonistic antibodies selectively induced apoptosis in malignant cells derived from...