They key toxic component of oleander is oleandrin. It only accounts for 0.08 % of total cardenolides and have a bioavailability of 30 %. The yellow flowered oleander contains Peruvoside.…
Thymidylate synthetase (TS) is a key enzyme in DNA synthesis, which catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). TS inhibition leads to deoxynucleotide imbalance and increased…
Iron is an essential nutrient required for DNA synthesis, energy production, and normal cellular growth. Meanwhile, Iron circulates in the plasma bound to transferrin (Tf). Particularly, Most cells express Tf…
Signal transducer and activator of transcription (STAT) protein is a family of cytoplasmic protein. STAT pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs…
In this article, we will introduce a potent, selective, and well-tolerated eIF4A inhibitor, Zotatifin. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM). Zotatifin…
Cdc42 is a member of the Rho GTPase family of low molecular weight G proteins. It is an important regulator of many biological processes. Besides, Cdc42 plays key roles in…