Ferristatin (NSC306711) is a Potent Iron Transport Inhibitor and Promotes Transferrin Receptor Degradation
Iron is an essential nutrient required for DNA synthesis, energy production, and normal cellular growth. Meanwhile, Iron circulates in the plasma bound to transferrin (Tf). Particularly, Most cells express Tf receptors on their surface to bind and internalize Tf by receptor-mediated endocytosis. Importantly, Study shows that alterations in the...
Ascochlorin Mediates Anti-tumor Effects through the Suppression of STAT3 Signaling Cascade
Signal transducer and activator of transcription (STAT) protein is a family of cytoplasmic protein. STAT pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. The transcription factors of this family dysregulation of this pathway are present in primary tumours...
Zotatifin is a Selective and Well-Tolerated eIF4A (Protein Biogenesis) Inhibitor
In this article, we will introduce a potent, selective, and well-tolerated eIF4A inhibitor, Zotatifin. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM). Zotatifin is able to induce the formation of a stable ternary complex [eIF4A-RNA-eFT226]. Additionally, it increases the residence time for...
ZCL278 is a Selective Cdc42 Inhibitor, with Antiviral Activity
Cdc42 is a member of the Rho GTPase family of low molecular weight G proteins. It is an important regulator of many biological processes. Besides, Cdc42 plays key roles in cytoskeletal organization, vesicular trafficking, cell cycle control, and transcription. As with most GTPases, transduction of signals occurs through the...