E3330, an APE1 Redox Inhibitor, Modulates Cell Migration and Invasion in Metastatic Cancer
AP endonuclease 1 (APE1; also known as REF-1) is a dual-function protein. It contains a redox domain and a DNA repair domain. Several human cancers overexpress APE1. Disruption of APE1 function has detrimental effects on cancer cell viability. Furthermore, APE1 implicates in the transactivation of numerous seminal transcription factors involved...