Tag: Aurora

AKI603 is an Aurora Kinase A Inhibitor with Anti-tumor Activity

Chemoresistance is a major cause of cancer treatment failure. Tumor-initiating cells (TIC) have attracted a considerable amount of attention due to their role in chemoresistance and tumor recurrence. The inhibition of AurA kinase by AKI603 abrogates the epirubicin-induced enrichment of TICs.In this study, researchers evaluated the small molecule Aurora...

AAPK-25 is a Selective and Dual Aurora/PLK Inhibitor

The occurrence of many cancers is due to a mismatch of chromosomes. It leads to the formation of aneuploidy and incomplete genes, and hence triggering an imbalance of cell cycles or divisions in the mitotic phase. Aurora and Polo-like kinases (PLKs) control the G2/M phase in cell mitosis. They are...