NHWD-870 is an Orally Active and Selective BET Bromodomain Inhibitor
Brominedomain can recognize acetylated lysine residues. As the “reader” of lysine acetylation, the bromine domain is responsible for the transduction of signals carried by acetylated lysine residues and transforming them into various normal or abnormal phenotypes. Specifically, the bromine domain-containing proteins have a variety of functions. Besides, it ranges...
IZCZ-3 is an Anticancer Agent by Blocking c-MYC Transcription
G-quadruplexes are unique four-stranded structures formed by guanine-rich nucleic acid sequences. G-quadruplexes are widely distributed in many important regulatory regions in the human genome, notably in telomeres and promoters of oncogenes, such as c-MYC, c-KIT, BCL-2, and KRAS. G-quadruplex structures play a significant regulatory role in many biological processes,...