FL118, a Camptothecin Analogue, is a Survivin Inhibitor with Anti-Cancer Activity
Survivin is the smallest member of the inhibitor of apoptosis (IAP) protein family. Specifically, survivin is a 142 amino acid, 16.5 kDa protein. Survivin participates in the inhibition of apoptosis and the regulation of the cell cycle. Besides, survivin can inhibit caspase and block cell death. Moreover, survivin was...
DRF-1042 is an Orally Active DNA topoisomerase I Inhibitor
Inhibitors of the enzyme topoisomerase I are cytotoxic for tumor cells because of their ability to cause DNA damage. Specifically, DNA Topoisomerase I (Top1) is one main cellular factor controlling topological homeostasis. Top1 activity can relax negative supercoils by cutting one of the DNA strands. This can create a...