Nowadays, Checkpoint inhibitors for cancer therapy have shown great benefits. Besides, amino acid metabolism is important in the regulation of the immune response. As the critical enzymes in metabolic pathways,…
HDAC inhibitors are a class of anticancer agents. HDAC inhibitors have shown antitumor effects in a variety of cancer cell lines, such as NSCLC, prostate, colon, ovarian, breast, bladder, pancreas,…
The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes. It plays an essential role in cardiac development during embryogenesis. Here, we will introduce…
Fms-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expresses on hematopoietic cells. However, FLT3 plays a critical role in both normal and malignant hematopoiesis. According to existing research…
Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of…
BBDDL2059 is a highly potent and selective covalent inhibitor of EZH2.
Breast cancer is the most common cancer in women all over the world. Breast cancer development is associated with abnormal cell proliferation and defects in apoptosis. Noticeably, Polo-like Kinases (PLKs)…
The retinoid X receptor (RXR) belongs to the nuclear receptor superfamily. The nuclear receptors superfamily has many other nuclear receptors, including the retinoic acid receptor (RAR), vitamin D receptor (VDR),…
Onvansertib, a PLK1-specific ATP competitive inhibitor, blocks the phosphorylation of PLK1 substrates. Polo was first identified in Drosophila melanogaster. The family of polo-like serine/threonine kinases includes 5 members: PLK1, PLK2,…
MEK (Mitogen-activated protein kinase kinase, MAPKK) is a kinase enzyme that phosphorylates mitogen-activated protein kinases (MAPKs). Firstly, the activated MAPK leads to the phosphorylation of downstream transcription factors that regulate…