LY3177833 is an Orally Active CDC7 and pMCM2 Inhibitor
CDC7 is a serine/threonine kinase and plays an important role in the initiation of DNA replication. . In this article, we will introduce a potent CDC7 and pMCM2 inhibitor LY3177833. LY3177833 has an IC50 of 3.3 nM against CDC7. Upregulation of CDC7 has been observed in numerous tumor cell...
CKI-7 is a Dual CK1 and Cdc7 Kinase Inhibitor
Protein phosphorylation plays a fundamental role in the regulation of a variety of cellular processes. Casein kinase I (CK1) is a cyclic nucleotide independent kinase. It is highly purified from various tissues, including calf thymus, rabbit reticulocytes, liver, and skeletal muscle. The widespread distribution of CK1 suggests its importance...