CZS-241 is an Orally Active and Selective PLK4 Inhibitor
PLK4 (polo-like kinase 4) is an enzyme that encodes a member of the polo family of serine/threonine protein kinases. Importantly, PLK4 protein localizes to centrioles—complex microtubule-based structures found in centrosomes-and regulates centriole duplication during the cell cycle. Particularly, PLK4 has been regarded as an extremely potential anticancer target, and...
SIAIS100 is a Potent BCR-ABL PROTAC Degrader
Chronic myeloid leukemia (CML) is a kind of myeloproliferative neoplasms (MPN). It is characterized by the proliferation of a pluripotential stem cell that can differentiate along the granulocytic lineage. In terms of mechanism, it is consistently related to the BCR-ABL1 fusion gene. CML is typically relevant to a balanced...