AMG 487, a Selective CXCR3 Antagonist, Has Potential to Treat Metastatic Cancer
In previous blog, we introduced AMG 487 as a potent, orally active and selective CXCR3 antagonist, which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50 values of 8.0 and 8.2 nM, respectively. Today, I’d like to describe the antitumor effect of AMG 487 on metastatic cancer....