DI-87 is an Orally Active and Selective Deoxycytidine Kinase (dCK) Inhibitor
Deoxyribonucleotide triphosphates (dNTPs) are essential for tumor growth, and DNA replication and repair also is essential dNTPs. Parallel and convergent de novo and salvage pathways redundantly produce the same dNTPs using different substrates. The de novo pathway produces dNTPs from glucose and amino acids and is dependent upon ribonucleotide reductase (RNR)....
DI-82 is a Potent Deoxycytidine Kinase (dCK) Inhibitor with Anti-tumor Acitivity
Deoxycytidine kinase (dCK) is an enzyme that is encoded by the DCK gene in humans. Specifically, dCK mainly phosphorylates deoxycytidine (DC) and converts DC into deoxycytidine monophosphate. Mall molecule dCK inhibitor can combine pharmacological disturbance of the de novo dNTP biosynthesis pathway. Besides, it can eliminate the acute lymphoblastic...