dBRD9 is a PROTAC and can Selective Degrades BRD9
BRD9 is a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex. Besides, BRD9 contains a bromodomain and is closely related to BRD7. Importantly, The BRD9 gene is frequently present in variable copy numbers in lung cancer and has emerged as an attractive therapeutic target in cancer. Moreover, the...
U7D-1 is a Selective USP7 PROTAC Degrader For Leukemia Research
Ubiquitin-specific proteinase 7 (USP7) is a kind of de ubiquitination enzyme (DUB), which can remove ubiquitin and protect substrate protein from degradation. Besides, the full activity of USP7 requires the C-terminal Ub-like domain to fold back to the catalytic domain. Moreover, this allows the active site to be remodeled...
ARV-471 is an Estrogen Receptor PROTAC Degrader for Breast Cancer
PROTAC is a heterobifunctional molecule containing two small molecule binding moieties. Specifically, PROTACs in cells seek and selectively bind to target proteins. PROTAC then recruits specific E3 ligases to the target protein. Besides, it forms a ternary complex in close proximity to the target protein and E3 ligase. In...