TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP
Apoptosis inhibitor proteins (IAP) represent a group of caspases and negative regulators of cell death. Particularly, the IAP protein family prevents cell death by binding to and inhibiting active caspases and is negatively regulated by IAP-binding proteins. In addition to cell death, IAP also acts as an innate immune...
EW-7195 is a Specific ALK5 (TGFβR1) Inhibitor with Anti-Metastasis Activity
Breast cancer is the leading cause of cancer mortality among women in Korea, England, and the United States of America. Invasion and metastasis are the most lethal characteristics of breast cancer. TGF-β signaling maintains homeostasis and elicits tumor-suppressive responses such as growth inhibition and apoptosis in normal mammary epithelial...