Tasisulam, an Antitumor Agent, Inhibits Mitotic Progression and Induces Apoptosis
Tasisulam is an acyl sulfonamide with a unique antitumor dual mechanism of action. It involves antiangiogenesis and mitotic inhibition. Tasisulam has a broad range of activity in 60 tumor cell lines. It includes leukemia, melanoma, non-small-cell lung cancer, colon, ovarian, renal, and breast cancers. In this study, Tasisulam is...
Alofanib, An Allosteric Inhibitor of FGFR2
FGF family participates in a variety of physiological processes in adult organism including regulation of angiogenesis. FGF acts via high affinity binding to specific receptors (FGFR) in various cells and stimulates cell proliferation, differentiation, and migration. Angiogenesis plays a pivotal role in the development of various physiological and pathological...