FA16 is a Specific Ferroptosis Inducer with Metabolic Stability
Ferroptosis is an iron-dependent form of regulatory cell death (RCD). Ferroptosis is an oxidative cell death distinct from apoptosis, driven by intense lipid peroxidation. System Xc–-GSH-GPX4 is the main ferroptosis inhibition pathway. Among them, system System Xc– is a cystine/glutamic acid antitransporter. It is responsible for the introduction of...
iFSP1 is a Selective FSP1 Inhibitor Glutathione-Independently
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids. Selenoenzyme GPX4 could control Ferroptosis. Flavoprotein apoptosis-inducing factor mitochondria-associated 2 (AIFM2) is an anti-ferroptosis gene. AIFM2 (ferroptosis suppressor protein 1, FSP1) confers protection against ferroptosis elicited by GPX4 deletion. The anti-ferroptosis function of FSP1...