TH1834 is a Specific Tip60 Histone Acetyltransferase (HAT) Inhibitor
Many aspects of genome regulation and metabolism require histone acetylation. Accordingly, dysfunctional histone acetylation has been implicated in numerous diseases, including cancer. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation of histones and non-histone. HATs catalyze the acetylation of core histones through the addition of an acetyl group...
CPTH2 is a Potent Histone Acetyltransferase (HAT) Inhibitor
Histone acetyltransferase (HATS) is an enzyme that acetylates the conserved lysine amino acids in histones by transferring acetyl from acetyl coenzyme A toε-N-acetyllysine. Several chromatin modifiers are responsible for adding different post-translational marks like acetylation, methylation, phosphorylation. Specifically, HATS add lysine at the N-terminal of acetyl histones H3 and...