GSK2606414 is an Orally Available PERK Inhibitor
PERK (Protein kinase R (PKR)-like endoplasmic reticulum kinase) is a type I endoplasmic reticulum transmembrane protein. Generally, PERK contains a stress-sensing domain facing the endoplasmic reticulum lumen and a cytosolic kinase domain. Interestingly, PERK is a major component of the unfolded protein response (UPR), which promotes the adaptation of...
BRD7389, a RSK Family Inhibitor, Induces Insulin Expression in Pancreatic α Cells
Colon cancer is one of the leading causes of cancer deaths worldwide. Multiple genetic alterations may cause colon cancer. The p90 ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases. RSKs regulate a wide range of target proteins, implicating RSKs in the control of cell cycle progression, protein...