Tetrac is a Thyrointegrin Receptor Antagonist
In the angiogenesis process, integrins are members of a family of cell surface transmembrane receptors. They play a critical role particularly in blood vessel formation and the local release of vascular growth factors. Thyroid hormones such as T4 and T3 promote angiogenesis and tumor cell proliferation via integrin αvβ3...
Cilengitide is a Selective Integrin Inhibitor for αvβ3 and αvβ5 Receptor
Integrins are heterodimeric cell surface adhesion receptors that consist of two noncovalently associated alpha and beta subunits. In particular, Integrins are heterodimeric transmembrane proteins composed of one α and one β subunit. Especially, Integrins are crucially important because they are the main receptor proteins that cells use to bind...
E7820 is an α2 Integrin Inhibitor with Anti-Tumor Activity
Vascular endothelial growth factor (VEGF) is a prime contributor to tumor angiogenesis. Most tumor cells produce high levels of VEGF and VEGF receptors associated with tumor endothelial cells. E7820 is an aromatic sulfonamide derivative and an Angiogenesis inhibitor. E7820 inhibits in vitro proliferation and tube formation of human umbilical...
Cyclo(-RGDfK) is a Selective Inhibitor of the αvβ3 Integrin
Increasing evidence indicated that targeting tumor angiogenesis for specific drug transfer into tumor masses and metastasis is a promising approach. On the one hand, integrin poorly expressed on quiescent vessels and selectively overexpressed on activated endothelial cells of growing vessels, on the other hand, integrin αvβ3 frequently overexpresses on...