Pimasertib is a Highly Selective and ATP non-Competitive Allosteric Inhibitor of MEK1/2
The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of proliferation and survival in human cancer cells. RAF is a serine/threonine kinase that activates downstream signals in response to activated GTP-bound RAS by phosphorylating MEK (MEK1 and MEK2). They in turn phosphorylate and activate MAPK (or ERK1 and ERK2)....
Deguelin, a Naturally Occurring Rotenoid, Acts as a Chemopreventive Agent
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers each year. In addition, breast cancer is a heterogeneous group of diseases. Approximately 60-70% of breast cancers express estrogen receptors (ER) and/or progesterone receptors (PR). About 20-30% of breast cancers have amplified levels of the...