CBP (cyclic AMP response element-binding protein) and P300 (E1A binding protein) are two non-BET bromodomain oncology targets. Additionally, P300 is a paralogue of CBP, and they conduct similar activity. Specifically, CBP and P300 are multidomain proteins containing bromodomain and other domains, such as lysine acetyl transferase (KAT). CBP/P300 bromodomains...