CCT369260 is an Orally Avtive B-cell Lymphoma 6 (BCL6) Inhibitor with Anti-Tumor Activity
BCL6 (B-cell lymphoma 6 protein) is a transcriptional repressor. Strikingly, this protein plays a key role in the formation and maintenance of germinal centers during the process of antibody affinity maturation. In addition, BCL6 represses genes involved in cell death, differentiation, and the DNA damage response. Most B-cell lymphomas...