Tag: PERK

GSK2606414 is an Orally Available PERK Inhibitor

PERK (Protein kinase R (PKR)-like endoplasmic reticulum kinase) is a type I endoplasmic reticulum transmembrane protein. Generally, PERK contains a stress-sensing domain facing the endoplasmic reticulum lumen and a cytosolic kinase domain. Interestingly, PERK is a major component of the unfolded protein response (UPR), which promotes the adaptation of...

CCT020312 is a Selective Activator of EIF2AK3/PERK

Genetic alterations that disable G1/S checkpoint control and loss of this checkpoint often happen in human cancer. The mechanisms contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle exit. Therefore, the active compounds activate the G1/S checkpoint. And they may represent a broadly applicable and...