Phosphatidylinositol (PI) is an essential phospholipid. Its related phosphatidylinositol kinases (PIK) play important roles in a number of human diseases. PI4KIIα is a member of the phosphatidylinositol kinase family. This kinase is not only the precursor of the important regulatory phosphoinositides PI(4,5)P2 and PI(3,4,5)P3, but also is an emerging...