MDL-800, a Selective SIRT6 Activator, Increases SIRT6 Deacetylation Activity
Sirtuins are evolutionarily conserved epigenetic proteins involved in diverse cellular processes in both prokaryotes and eukaryotes. Among them, Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD+-dependent deacetylases. SIRT6 regulates glucose homeostasis in the liver. The overexpression of SIRT6 inhibits the phosphorylation of ERK1/2 and thus...
SRT 2183, a Selective Sirtuin-1 Activator, Induces Growth Arrest and Apoptosis
Sirtuin-1 (SIRT1) , is an NAD+-dependent class III HDAC. Previous studies have showed SIRT1 as regulator of diverse physiological functions, including metabolic responses to caloric restriction and exercise training, circadian rhythm, DNA repair, cell survival, senescence, death, and differentiation. Furthermore, SIRT1 also is potential for SIRT1 in diabetes, cardiovascular...