Tag: T Cell

SIS3 is a Potent and Selective Inhibitor of Smad3 Phosphorylation

Smad contains a series of proteins with similar structures, which are the main signal transducer in transforming growth factors β (TGF-b) superfamily. Specifically, they play an important role in the regulation of cell development and growth. One mechanism of Smads promoting TGF-b-induced cell arrest is down-regulation of Myc, a...

BMSpep-57 is a Competitive Peptide Inhibitor of PD-1/PD-L1 Interaction

Programmed cell death 1 (PD-1) is a cell surface receptor. PD-1 is highly expressed on tumor-specific T cells. It is a T cell checkpoint and plays a central role in regulating T cell exhaustion. Programmed cell death ligand 1 (PD-L1) is a trans-membrane protein.  PD-L1 is a co-inhibitory factor...

DS-437 is a Dual PRMT5/7 Inhibitor

Protein arginine methyltransferases are a class of enzymes. They transfer a methyl group from the cofactor S-adenosylmethionine (SAM) onto the arginine omega nitrogens of substrate proteins, including histones. There are three subclasses based on their product specificity: type I, II, and III PRMTs asymmetrically dimethylate, symmetrically dimethylate, and monomethylate their...