KU-0060648 is a Dual PI3K and DNA-PK Inhibitor
DNA double-strand breaks (DSBs) are the principal cytotoxic lesions induced by topoisomerase II poisons. And DSB inhibitors are widely applied in the treatment of a variety of human solid malignancies…
DNA double-strand breaks (DSBs) are the principal cytotoxic lesions induced by topoisomerase II poisons. And DSB inhibitors are widely applied in the treatment of a variety of human solid malignancies…
Nowadays, liver cancer becomes more frequent among various kinds of diseases. There are many factors leading to liver cancer, such as hepatitis B, hepatitis C, or alcohol. Except for these,…
Hepatocellular carcinoma represents an aggressive cancer with poor prognosis. Fibroblast growth factor 19, a member of the fibroblast growth factor family, is a ligand for fibroblast growth factor receptor 4.…
Sirtuins are evolutionarily conserved epigenetic proteins involved in diverse cellular processes in both prokaryotes and eukaryotes. Among them, Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD+-dependent…