BSJ-03-123, a Degrader with Proteome-wide Selectivity for CDK6 (PROTAC)
A study from Matthias Brand reported a novel phthalimide-based degrader BSJ-03-123. This compound exploits protein-interface determinants to achieve proteome-wide selectivity for the degradation of cyclin-dependent kinase 6 (CDK6). Notably, CDK6…