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Reliable, unbiased and up to date information in cancer research

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Breast Cancer Pancreatic Ductal Adenocarcinoma

MPT0B014, a Tubulin Polymerization Inhibitor Induces Cancer Cell Apoptosis

Louis Gilman March 22, 2023

Microtubules are polymers of microtubule proteins that form part of the cytoskeleton and provide structure and shape for eukaryotic cells. Specifically, Microtubules play an important role in many cellular processes.…

NSCLC

Talotrexin, A RFC Specific Inhibitor, Targets DHFR to Inhibit Tumor Growth

Louis Gilman February 24, 2023

In this article, we will introduce a potent RFC (reduced folate carrier) specific inhibitor Talotrexin (PT523). Talotrexin, an analog of Aminopterin, is a nonpolyglutamatable classic antifolate. Additionally, it selectively inhibits…

Chronic Myeloid Leukemia Colorectal Cancer Leukemia Lung Adenocarcinoma

MC2590, a Potent HDAC Inhibitor, inhibits HDAC1-3, -6, -8, and -10

Louis Gilman February 10, 2023

Histone deacetylase (HDAC) is an epigenetic enzyme that regulates gene expression through histone deacetylation. It leads to more closed chromatin structure and gene expression inhibition. Many non-histones are also targets…

Lung Cancer Non-Small Cell Lung Cancer

Brusatol (NSC 172924) is a Nrf2 Inhibitor

Louis Gilman October 26, 2021

Keap1-Nrf2 is the major regulator of cytoprotective responses to electrophilic chemicals or reactive oxygen species (ROS).  Upregulation of Nrf2 inducing by inactivation of Keap1 is often observed in cancer cells.…

Cancer Lung Cancer Non-Small Cell Lung Cancer

Rapamycin is a Specific mTOR Inhibitor

Louis Gilman August 25, 2021

mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell…

Breast Cancer Lung Cancer

GGTI-2154 is a Selective Geranylgeranyltransferase I (GGTase I) Inhibitor

Louis Gilman July 22, 2021

The Ras superfamily of low molecular weight GDP/GTP-binding GTPases is critical in the regulation of many important biological events. They include the cell division cycle, survival and death, differentiation, and…

Colorectal Cancer Lung Cancer Myeloma

PTC-209 is a Specific BMI-1 Inhibitor and Impairs the Tumor Microenvironment

Louis Gilman June 10, 2021

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. BMI-1 is part of the polycomb repressive complex 1 (PRC1). There is a statistically…

Cancer

APS-2-79 is a KSR-Dependent Antagonist of RAF-Mediated MEK Phosphorylation

Louis Gilman April 15, 2021

Deregulation of the Ras-MAPK pathway is an early event in many different cancers and a key driver of resistance to targeted therapies. Kinase suppressor of Ras (KSR) is a MAPK…

Cervical Cancer Lung Cancer Non-Small Cell Lung Cancer

IMT1 is a First-in-Class Specific and Noncompetitive Human POLRMT Inhibitor

Louis Gilman March 13, 2021

Mitochondria provide cellular energy through its oxidative phosphorylation system, which needs to coordinate the expression of genes encoded by nuclear and mitochondrial genomes (mtDNA). Specifically, the transcription of mtDNA in…

Colon Cancer Lung Cancer Lymphoma

CXD101 is a Selective and Orally Active Class I HDAC Inhibitor

Louis Gilman February 16, 2021

Aberrant expression of classical HDACs associates with a variety of malignancies, including solid and hematological tumors. HDACs have also been found broadly dysregulated in multiple myeloma (MM). In particular, the…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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