β-Amanitin is a cyclic peptide toxin, inhibits eukaryotic RNA polymerase II and III and protein synthesis.
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. Besides, β-Amanitin inhibits eukaryotic RNA polymerase II and III. It inhibits DNA transcription and protein synthesis. Moreover, β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs). β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in...
Telomestatin, a Potent Telomerase Inhibitor, Facilitates the Formation of Intramolecular G-quadruplexes
Telomestatin is a very potent telomerase inhibitor and can be isolated from Streptomyces anulatus 3533-SV4. It selectively facilitates the formation of intramolecular G-quadruplexes, in particular, that produced from the human telomeric sequence d[T2AG3]4. Firstly, in vitro, Telomestatin promotes or stabilizes the formation of the intramolecular G-quadruplex. When the DNA concentrations are at 0.005...