Rebeccamycin, an Antitumor Antibiotic, Inhibits DNA Topoisomerase I
Rebeccamycin, a yellow crystalline product, is isolated from the mycelium. It has activity against P388 leukemia, L1210 leukemia, and B16 melanoma implanted in mice. Rebeccamycin is also an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116...
Pirarubicin, an Anthracycline Antibiotics, Acts as a Topoisomerase II Inhibitor
Pirarubicin has widely application in intravesical chemotherapy for bladder cancer, but drug resistance limits its efficacy; the mechanism still needs further exploration. Bladder cancer is the most common malignancy of the urinary tract in China. 75–85% of bladder cancers are grouped as non-muscle invasive bladder tumors. Intravesical chemotherapy...
Anisomycin, a Protein Synthesis Inhibitor, also Interferes DNA Synthesis
Protein synthesis is a core biological process, which balances the loss of cellular proteins by producing new proteins. Specifically, proteins perform many key functions as enzymes, structural proteins, or hormones. Besides, protein synthesis includes two stages – transcription and translation. During transcription, a DNA fragment encoding a protein is...