Obrindatamab is a Humanized Anti-B7-H3/CD3 Bispecific Antibody for Cancer Research
B7-H3 (CD276) is a T cell co-stimulator and co-suppressor molecule. Specifically, B7-H3 plays an important role in tumor cell apoptosis, proliferation, adhesion, angiogenesis, invasion, migration, and escape from immune surveillance. Effects of B7-H3 on T cell proliferation, activation, and IFN in vitro-γ show a positive regulatory function during production....
Bapotulimab (BAY-1905254) is an IgG2 Antibody Targeting ILDR2
Immunoglobulin-like domain containing receptor 2 (ILDR2) is a B7-like protein that belongs to the B7 family of immunomodulatory receptors. It can induce an immunosuppressive effect on T-cell responses. ILDR2 is a negative regulator for T cells. Besides, ILDR2 is expressed in immune cells and in immune-privileged and inflamed tissues....