ENMD-1198, an Orally Active Tubulin-Binding Agent, Reduces HIF-1α and STAT3 Activity
Hepatocellular carcinoma (HCC) is the fifth most cancer worldwide, with a continuously increasing incidence. HCC represents a hyper vascularized tumor and its progression is closely related to angiogenesis. Hepatocellular carcinoma overexpresses the vascular endothelial growth factor (VEGF). The transcription factor HIF-1α also plays a central role in HCC progression...
DMU-212 Possesses Antimitotic, Anti-Proliferative, Antioxidant and Apoptosis Promoting Activities
Resveratrol is a naturally occurring phytoalexin that possesses a wide diversity of anticancer effects. Especially, Resveratrol inhibits multi-kinase enzyme activity and induces apoptosis. In particular, DMU-212 is a Resveratrol analogue containing methoxy groups in place of the hydroxyl groups of the stilbene moiety. DMU-212 inhibits cellular proliferation of A375,...