BrBzGCp2 is a Glyoxalase 1 Inhibitor, with Antitumor and Neuroprotective Activity
The glyoxalase system is a ubiquitous enzymatic network that plays important role in biological life. The glyoxalase system consists of glyoxalase 1 (GLO1), glyoxalase 2 (GLO2), and reduced glutathione (GSH). They perform an essential metabolic function in cells by detoxifying methylglyoxal (MG). GLO performs an essential metabolic function by...
MBQ-167 as a Dual Rac/Cdc42 Inhibitor in Metastatic Cancer
Rho GTPases participate in the regulation of cell migration, invasion, apoptosis, cell-to-cell and cell-to-extracellular matrix adhesions. The Rho GTPases Rac and Cdc42 potently induce actin polymerization. In addition, Cdc42 plays a critical role in cell polarity. Increasing studies have identified the effect of hyperactive Rac and Cdc42 on cancer...