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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Reliable, unbiased and up to date information in cancer research

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Breast Cancer Leukemia

LFM-A13 is a BTK/PLK Inhibitor for Breast Cancer Research

Louis Gilman September 8, 2023

Breast cancer is the most common cancer in women all over the world. Breast cancer development is associated with abnormal cell proliferation and defects in apoptosis. Noticeably, Polo-like Kinases (PLKs)…

Anti-angiogenic anti-inflammatory antioxidant Breast Cancer Cancer

Rhamnazin is an Orally Active VEGFR2 Inhibitor for Breast Cancer Research

Louis Gilman May 29, 2023

Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) play a crucial role in angiogenesis and angiogenesis. Specifically, the VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor…

Chronic Myeloid Leukemia

CZS-241 is an Orally Active and Selective PLK4 Inhibitor

Louis Gilman March 28, 2023

PLK4 (polo-like kinase 4) is an enzyme that encodes a member of the polo family of serine/threonine protein kinases. Importantly, PLK4 protein localizes to centrioles—complex microtubule-based structures found in centrosomes-and…

Anti-angiogenic Cancer Colon Cancer

Pegdinetanib (BMS-844203) is a Selective VEGFR-2 Inhibitor

Louis Gilman February 13, 2023

Pegdinetanib (BMS-844203), an anti-angiogenic therapeutic agent, exemplifies a new class of targeted biologics called Adnectins. Adnectins are genetically engineered variants of the tenth type III domain of human fibronectin. Firstly,…

Acute Leukemia Melanoma

Salviolone is a Natural Diterpenoid Derivative That Can Against Melanoma Cells

Louis Gilman January 11, 2023

Melanoma is a type of skin cancer that is caused by a malignant proliferation of melanocytes. Ultraviolet light (UV) exposure can change DNA and its expressions and is the primary…

Breast Cancer Cancer Lung Cancer

CYD-2-11 is a Selective Bax Agonist for Breast and Lung Cancer Research

Louis Gilman December 5, 2022

Bax, an important regulator of cell death is expressed in essentially all organs. Also, Bax is a member of B-cell lymphoma 2, it is involved in the apoptosis of normal…

Cancer Lung Cancer Pancreas Cancer

Reversin 121, a P-glycoprotein Inhibitor, Reverses P-glycoprotein-Mediated Multidrug Resistance

Louis Gilman December 1, 2022

Nowadays, how to overcome the resistance of tumor cells to multiple drugs is still a serious problem. Various mechanisms can cause Multidrug resistance (MDR), including cell cycle alterations, increased repair…

Cervical Cancer Triple-Negative Breast Cancer

STX-0119 is a Selective, Orally Active STAT3 Dimerization Inhibitor

Louis Gilman November 21, 2022

STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many…

Cancer

RP-6685 is an Orally Active DNA Polθ Inhibitor

Louis Gilman October 27, 2022

DNA polymerase theta (Polθ) is a unique, large (290 kDa) multifunctional A-family DNA polymerase that is required for DNA double-strand breaks (DSBs) repair through the microhomology-mediated end-joining (MMEJ) pathway. Importantly, MMEJ is…

Cancer

SHR2415 is a Selective and Orally Active ERK1/2 Inhibitor

Louis Gilman September 27, 2022

ERKs (extracellular signal-regulated kinases) are the original members of the mitogen-activated protein kinase (MAPK) family. They take part in the regulation of meiosis, mitosis, and postmitotic functions, thus, also influencing…

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  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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