Salviolone is a Natural Diterpenoid Derivative That Can Against Melanoma Cells
Melanoma is a type of skin cancer that is caused by a malignant proliferation of melanocytes. Ultraviolet light (UV) exposure can change DNA and its expressions and is the primary cause of melanoma. Applying sunscreen and avoiding UV light can help prevent melanoma to some extent. For patients who...
CYD-2-11 is a Selective Bax Agonist for Breast and Lung Cancer Research
Bax, an important regulator of cell death is expressed in essentially all organs. Also, Bax is a member of B-cell lymphoma 2, it is involved in the apoptosis of normal and cancer cells. The mitochondrial pathway is the intrinsic pathway that leads to apoptosis. Importantly, activation of Bax induces...
Reversin 121, a P-glycoprotein Inhibitor, Reverses P-glycoprotein-Mediated Multidrug Resistance
Nowadays, how to overcome the resistance of tumor cells to multiple drugs is still a serious problem. Various mechanisms can cause Multidrug resistance (MDR), including cell cycle alterations, increased repair of damaged DNA and activation of detoxifying systems. Noticeably, ATP-binding cassette proteins are the most significant factor in drug...
STX-0119 is a Selective, Orally Active STAT3 Dimerization Inhibitor
STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many human cancer cells. Specifically, it transmits signals of cytokines and growth factors from the cell membrane to the nucleus...
RP-6685 is an Orally Active DNA Polθ Inhibitor
DNA polymerase theta (Polθ) is a unique, large (290 kDa) multifunctional A-family DNA polymerase that is required for DNA double-strand breaks (DSBs) repair through the microhomology-mediated end-joining (MMEJ) pathway. Importantly, MMEJ is intrinsically mutagenic, whereas break sites are often scarred with insertions and deletions. Besides, increasing evidence suggests that MMEJ is...
SHR2415 is a Selective and Orally Active ERK1/2 Inhibitor
ERKs (extracellular signal-regulated kinases) are the original members of the mitogen-activated protein kinase (MAPK) family. They take part in the regulation of meiosis, mitosis, and postmitotic functions, thus, also influencing the development of cancer. ERK1 and ERK2 are important downstream points of the RAS-RAF-MEK-ERK signaling pathway. The two targets...
Simmiparib is An Orally Active PARP1/2 Inhibitor
Poly (ADP-ribose) polymerase (PARP), a family of proteins, is involved in various cellular processes such as DNA repair and programmed cell death. PARP is present in the cell nucleus. It consists of a DNA-binding domain, a caspase-cleaved domain, an auto-modification domain, and a catalytic domain. In particular, the protein...