Tag: Antitumor

CYD-2-11 is a Selective Bax Agonist for Breast and Lung Cancer Research

Bax, an important regulator of cell death is expressed in essentially all organs. Also, Bax is a member of B-cell lymphoma 2, it is involved in the apoptosis of normal and cancer cells. The mitochondrial pathway is the intrinsic pathway that leads to apoptosis. Importantly, activation of Bax induces...

STX-0119 is a Selective, Orally Active STAT3 Dimerization Inhibitor

STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many human cancer cells. Specifically, it transmits signals of cytokines and growth factors from the cell membrane to the nucleus...

RP-6685 is an Orally Active DNA Polθ Inhibitor

DNA polymerase theta (Polθ) is a unique, large (290 kDa) multifunctional A-family DNA polymerase that is required for DNA double-strand breaks (DSBs) repair through the microhomology-mediated end-joining (MMEJ) pathway. Importantly, MMEJ is intrinsically mutagenic, whereas break sites are often scarred with insertions and deletions. Besides, increasing evidence suggests that MMEJ is...

SHR2415 is a Selective and Orally Active ERK1/2 Inhibitor

ERKs (extracellular signal-regulated kinases) are the original members of the mitogen-activated protein kinase (MAPK) family. They take part in the regulation of meiosis, mitosis, and postmitotic functions, thus, also influencing the development of cancer. ERK1 and ERK2 are important downstream points of the RAS-RAF-MEK-ERK signaling pathway. The two targets...

Simmiparib is An Orally Active PARP1/2 Inhibitor

Poly (ADP-ribose) polymerase (PARP), a family of proteins, is involved in various cellular processes such as DNA repair and programmed cell death. PARP is present in the cell nucleus. It consists of a DNA-binding domain, a caspase-cleaved domain, an auto-modification domain, and a catalytic domain. In particular, the protein...