Rho GTPases participate in the regulation of cell migration, invasion, apoptosis, cell-to-cell and cell-to-extracellular matrix adhesions. The Rho GTPases Rac and Cdc42 potently induce actin polymerization. In addition, Cdc42 plays a critical role in cell polarity. Increasing studies have identified the effect of hyperactive Rac and Cdc42 on cancer...