AUTAC2 is a FKBP12-Targeting Autophagy-Mediated Degrader (AUTAC)
Autophagy-targeting chimera (AUTAC) is a technology that selectively degrades intracellular proteins and intracellular debris through the autophagy pathway. An AUTAC molecule contains a degradation tag (guanine derivative) and a ligand of the protein of interest (POI) to provide target specificity. AUTAC can selectively recognize and degrades a broad range...
AUTAC4 is a Mitochondria-Targeting Autophagy-Targeting Chimera (AUTAC)
A novel chimeric molecule, namely autophagy-targeting chimera (AUTAC), is the first degrader using the autophagy mechanism. AUTAC consists of a guanine tag and a specific binder of an intracellular target of interest. In addition, AUTAC can penetrate cell membranes, and degrade fragmented mitochondria as well as proteins. Mitochondria not...