Tag: CDK

NU6102 is a Potent CDK1 and CDK2 Inhibitor

CDKs remain attractive targets for anti-proliferative cancer chemotherapy. they play a central role in cell division and growth.  Amongst the cell cycle CDKs, CDK2 has attracted the most attention and its exploitation as a drug target based on structure-based drug design. In this article, we will introduce a potent...

OTS964 is an Orally Active TOPK and CDK11 Inhibitor

TOPK (T–lymphokine-activated killer cell–originated protein kinase, also known as PBK or PDZ-binding kinase) is a Ser/Thr protein kinase. Many types of human cancer, including breast and lung cancers, highly expresses it. Thus, TOPK might be a promising molecular target for drug development. Moreover, TOPK is in the “consensus stemness...