Tag: Chk1

SAR-020106 is an ATP-Competitive and Selective CHK1 Inhibitor

Genotoxic antitumor drugs cause DNA damage and activate cell cycle checkpoints, which are required for DNA repair and the maintenance of genomic integrity. The transcription factor p53 is a critical checkpoint protein. As a result, in the presence of damaged DNA, p53 stabilized and activated, causes the upregulation of...

SB-218078 is an ATP Competitive and Reversible Chk1 Inhibitor

Research from Jeffrey R. Jackson, et al. discovered and identified an indolocarbazole inhibitor of human checkpoint Kinase (Chk1) SB-218078. SB-218078 is an ATP Competitive and Reversible Chk1 Inhibitor The regulation of cell cycle checkpoints is a critical determinant of the manner in which tumor cells in response to chemotherapies...