FTI-277 is a Farnesyl Transferase (FTase) Inhibitor
Farnesyl transferase (FTase) is a zinc-dependent enzyme. It adds a 15-carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif. FTase regulates the activation of oncogenic Ras protein and consequently affects intracellular signal transduction, and cell proliferation. Ras-induced malignant transformation requires Ras farnesylation, a lipid posttranslational modification...
FTI-2153 is a Highly Selective Farnesyltransferase Inhibitor
Farnesyltransferase (FTase) is a zinc enzyme that has been the subject of particular attention in anti-cancer research. Inhibitors of farnesyltransferase (FTase) have been designed for use as anti-Ras and anti-cancer drugs, but in fact they are selective for FTase, not for Ras. The non-thiol-containing FTI-2148 is highly selective for...
FGTI-2734, a Dual FTase and GGTase Inhibitor, Has Potential to Treat KRAS-mutant Cancer
The KRAS gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. The KRAS gene is in the Ras family of oncogenes, which also includes two other genes: HRAS and NRAS. These proteins play important roles...