BMS453 is a RARβ Agonist and a RARα/RARγ Antagonist
Retinoids inhibit the growth of many human tumor cells. Retinoids are ligands of retinoic acid receptors alpha, beta, gamma (RARs, α, β and γ). Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. BMS453 is...
BSJ-03-204 is a Selective Palbociclib-Based CDK4/6 Dual Degrader (PROTAC)
The chimeric proteolytic enzyme (PROTAC) is a heterobifunctional small molecule. Specifically, it is composed of two active domains and an adaptor that can remove specific proteins that are not needed. Besides, PROTAC does not act as a conventional enzyme inhibitor, but by inducing selective intracellular proteolysis. Moreover, PROTAC includes...