Telaglenastat is a Selective and Orally Active Inhibitor of Glutaminase 1
Tumor cells use a variety of oncogenically- and environmentally driven metabolic pathways. That aims to meet the bioenergetic and biosynthetic demands of rapid and sustained growth. One of the key nutrients is the amino acid glutamine. It is the most abundant amino acid in plasma. Small-molecule inhibitors, suppressing the...
UPGL00004 is a Potent Allosteric and Orally Active Glutaminase C Inhibitor
The Warburg effect in cancer cells refers to the significant alteration of the glycolytic pathway. It increases the generation of lactate, decreases mitochondrial metabolism of pyruvate, and accompanying with the reduction in oxidative phosphorylation. The Warburg effect has a significant consequence. Cancer cells need to develop alternative mechanisms that...