GGTI-2154 is a Selective Geranylgeranyltransferase I (GGTase I) Inhibitor
The Ras superfamily of low molecular weight GDP/GTP-binding GTPases is critical in the regulation of many important biological events. They include the cell division cycle, survival and death, differentiation, and development. These GTPases also show a relation with oncogenesis, Ras and Rho proteins mediate malignant transformation, invasion, and metastasis....
FTI-2153 is a Highly Selective Farnesyltransferase Inhibitor
Farnesyltransferase (FTase) is a zinc enzyme that has been the subject of particular attention in anti-cancer research. Inhibitors of farnesyltransferase (FTase) have been designed for use as anti-Ras and anti-cancer drugs, but in fact they are selective for FTase, not for Ras. The non-thiol-containing FTI-2148 is highly selective for...