NV03 is a Selective Antagonist for UHRF1-TTD Interaction with H3K9me3
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a potent oncogenic protein. Its overexpression in various solid and blood tumors. Moreover, UHRF1 has an association with reduced expression of tumor suppressor genes, including BRCA1 and PPARγ. UHRF1 contains five functional domains, and each domain could independently carry...
YUKA1, a Specific KDM5A Inhibitor, Inhibits Drug Resistance
KDM5A (Lysine-specific demethylase 5A) is a histone lysine demethylase, which binds with other proteins to retinoblastoma protein. The latter regulates cell proliferation. KDM5A exhibits high levels of some human cancers. It involves cancer processes, such as tumorigenesis, metastasis, and drug tolerance. Therefore, we need to found out more KDM5A...
MS31 is a Highly Selective Spindlin 1 Inhibitor
SPIN1 (Spindlin 1) is a chromatin reader protein. It recognizes trimethylated histone H3 lysine 4 (H3K4me3) through the protein-protein interaction at the defined “aromatic cage” in Tudor domain II. The interaction between asymmetrically dimethylated histone H3 arginine 8 (H3R8me2a) and Tudor domain I further increases the affinity. On the...