GNE-371, a Chemical Probe for the Second Bromodomains of TFIID Subunit 1 and TFIID Subunit 1-Like
Bromodomains are protein modules that serve as epigenetic readers. These modules consist of 110 amino acids, specifically recognize acetylated lysine residues on histone tails. They also play important roles in chromatin-structural changes and transcriptional regulation. A number of inhibitors of the bromodomain and extra terminal (BET) family and non-BET...