Mepazine, an Apoptosis Enhancer, is a Potent and Selective MALT1 Inhibitor
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), a positive regulator of NF-κB, is amongst the top highly induced genes. In lymphocytes, MALT1 regulates NF-κB signaling through a scaffold function that transduces signals from the CBM complex to TRAF6, which subsequently activates downstream signaling. As a paracaspase, MALT1 also...