CYD-4-61 is a Bax Activator Used for Breast Cancer Research
Bax is an apoptosis regulator, belonging to the Bcl-2-like protein family. It controls mitochondrial dysfunction and apoptosis. Bax can promote apoptosis by forming a heterodimer with Bcl-2 to become a lethal mitochondrial pore protein. Specifically, it can induce mitochondrial outer membrane permeability, release cytochrome c, and cause programmed death...
STX-0119 is a Selective, Orally Active STAT3 Dimerization Inhibitor
STAT3 protein is a potential cytoplasmic transcription factor. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is related to the proliferation, survival, invasion, and angiogenesis of many human cancer cells. Specifically, it transmits signals of cytokines and growth factors from the cell membrane to the nucleus...
AZ9482 is a Triple PARP1/2/6 Inhibitor
PARPs are implicated in a variety of cellular metabolic processes including DNA-damage repair and mitotic spindle formation. In particular, PARP1 is essential in repairing DNA single- and double-strand breaks. For example, PARP1 Inhibitor Olaparib is an effective synthetic lethal strategy in cancer. Recently, scientists reported a triple PARP1/2/6 inhibitor,...