Rosabulin is a Potent Microtubule Inhibitor
Chemotherapy is a cornerstone in the development of present-day cancer therapy. Moreover, Chemotherapy is one of the most effective and potent strategies to treat malignant tumors. However, Chemotherapy resistance occurs when cancers that have been responding to therapy suddenly begin to grow. Rosabulin is a potent tubulin inhibitor. In...
Verucopeptin, a HIF-1 and v-ATPase ATP6V1G Inhibitor, Exhibits Antitumor Activity Against MDR Cancers
ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase). In this article, we will introduce a potent ATP6V1G inhibitor, Verucopeptin. Firstly, in vitro. Verucopeptin shows excellent antitumor activity against K562R cells, with an IC50 of 388 nM. Although these cells exhibit resistance to some other chemotherapeutic agents, such as Taxol...