RU-302, a pan-TAM Inhibitor, Blocks Gas6-Inducible TAM Activation and Tumorigenicity
The TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous types I receptor tyrosine kinases (RTKs). They play an indispensable role in homeostasis and the resolution of inflammation under physiological conditions. Pathophysiologically, TAMs frequently overexpressed in a wide variety of human cancers that are associated with...