Tag: p21

UC2288 is an Orally Active p21 Attenuator

p21 is a member of the cip/kip family of cyclin-dependent kinase inhibitors, it regulates cell growth in both malignant or non-malignant cells. It possesses diverse physiological functions in vitro, such as vascular smooth muscle cell proliferation, cancer progression, and viral infection. p21 is well-known as a tumor suppressor protein...

MI-773 is an MDM2 Inhibitor for Adenoid Cystic Carcinoma Therapy

Adenoid Cystic Carcinoma (ACC) is a rare kind of cancer, occurs in different tissues or organs. It commonly happens in salivary glands, and also exists in breast, lung, brain and the paranasal sinuses. The disease causes a lot of death all around the world. p53 (Tumor protein p53) is...

FT671, a USP7 Inhibitor, Increases p53 Expression

A study from Andrew P. Turnbull reported two compounds, FT671 and FT827, as USP7 (ubiquitin-specific protease 7) inhibitors. Ubiquitination controls the stability of most cellular proteins, and its deregulation can lead to human diseases, including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibitory effects can induce degradation of...

CB-6644 is an Inhibitor of the RUVBL1/2 Complex

RUVBL1 and RUVBL2 are related ATPase associated with diverse cellular activities proteins. RUVBL2 is a human gene coding for a protein belonged to the diverse cellular activities family of proteins. RUVBL1 can form a hexamer with RUVBL2 protein. Both RUVBL1 and RUVBL2 can bind to nucleosomes. RUVBL1 and RUVBL2...