UMB298 is a Selective CBP (P300) Bromodomain Inhibitor
CBP (cyclic AMP response element-binding protein) and P300 (E1A binding protein) are two non-BET bromodomain oncology targets. Additionally, P300 is a paralogue of CBP, and they conduct similar activity. Specifically, CBP and P300 are multidomain proteins containing bromodomain and other domains, such as lysine acetyl transferase (KAT). CBP/P300 bromodomains...
DCH36_06 is a Selective p300/CBP Inhibitor
Histone acetyltransferases (HATs) are epigenetic enzymes that relieve transcriptional repression by preferentially acetylation of ε-amino group of lysine residues on histones. In general, HATs are crucial for chromatin restructuring and transcriptional regulation in eukaryotic cells. HATs can be grouped into at least five different subfamilies (HAT1, Gcn5/PCAF, MYST, p300/CBP,...
dCBP-1 is a Selective PROTAC Degrader of p300/CBP
The paralogous chromatin regulators CREB-binding protein (CBP) and p300 are factors critical for establishing and activating enhancer-mediated transcription. The CREB-binding protein (CBP) and p300 are important factors for activating enhancer-mediated transcription. These proteins consist of at least 10 distinct functional domains. Most of them interact with over 400 other proteins,...