SOR-C13 is a High-Affinity TRPV6 Antagonist for Advanced Solid Tumors Research
The Vanilloid group (TRPV) contains six members, from TRPV1 to TRPV6. TRPV5 and TRPV6 exhibit lower sequence identity to V1-V4, and different properties. Additionally, TRPV5 or TRPV6 is selective for calcium ions. The major function of TRPV5/6 is larger-scale calcium homeostasis. Besides, Mice with TRPV6 knock-outs exhibit defective intestinal...
SR7826 is a Selective and Orally Active LIM kinase (LIMK) Inhibitor
LIM-kinase (Limk) is a serine-threonine protein kinase. Two isoforms are LIM kinase 1 (Limk1) and LIM kinase 2 (Limk2). Limk1 is overexpressed in cancerous prostate cells and tissues. Previous studies shows that the possibility of up-regulated Limk1 as a cellular oncogene and inhibition of Limk1 activity in cancerous prostate...