AZD1208 is an Orally Bioavailable and Highly Selective PIM Kinases Inhibitor
Pim kinases, also known as serine/threonine kinases, have three highly homologous isoforms namely Pim-1, Pim-2, and Pim-3. And Pim-1, Pim-2, and Pim-3 are recurrent proviral integration locus in Moloney murine leukemia virus. The overexpression of Pim kinases occurs when viral inserts at this site. Pim kinases are overexpressed in...
GNE-955 is a Potent Pan-Pim Inhibitor for Multiple Myeloma and Leukemia Research
Leukemia is a group of blood cancers, such as acute leukemia, as we mentioned in our previous blog “BSc5371, an Irreversible FLT3 Inhibitor for Acute Leukemia Treatment”. Multiple myeloma is a cancer of plasma cells, called plasma cell myeloma. Such diseases severely affect patients’ lives. What is worse, they...